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By 2005, he was ready to headline movies himself, pulling in a strong performance as Jim, the depressed, Midwestern aspiring writer of "Lonesome Jim" (2005), before tackling the adult responsibilities of marriage and fatherhood in the ensemble drama, "The Last Kiss" (2006)

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In this article, we conduct a literature review to assess the data on IQOS toxicity and health impact published by PMI-sponsored research (affiliated authors or funded studies) and independent research